Lynn Y Sakai Selected Research

Weill-Marchesani Syndrome

9/2015	The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation?
4/2014	Early fibrillin-1 assembly monitored through a modifiable recombinant cell approach.
5/2011	ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts.

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Lynn Y Sakai Research Topics

Disease

10	Marfan Syndrome (Marfan's Syndrome) 01/2020 - 12/2002
3	Aneurysm (Aneurysms) 04/2022 - 03/2006
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 06/2010
3	Weill-Marchesani Syndrome 09/2015 - 05/2011
3	Contracture 06/2015 - 01/2003
2	Thoracic Aortic Aneurysm 01/2021 - 10/2013
2	Congenital contractural arachnodactyly 06/2015 - 12/2002
2	Hypertrophy 06/2015 - 07/2010
2	Emphysema 06/2011 - 03/2003
1	Aortic Aneurysm (Aneurysm, Aortic) 04/2022
1	Aortic Diseases 01/2020
1	Fibrosis (Cirrhosis) 01/2020
1	Heart Arrest (Cardiac Arrest) 01/2020
1	Inflammation (Inflammations) 01/2020
1	Necrosis 01/2020
1	Proteinuria 01/2020
1	Cardio-Renal Syndrome 01/2020
1	Pulmonary Hypertension 01/2017
1	Pulmonary Arterial Hypertension 01/2017
1	Hypertension (High Blood Pressure) 01/2017
1	Obesity 01/2016
1	Brachydactyly 09/2015
1	Joint Instability (Joint Laxity) 09/2015
1	Arachnodactyly 09/2015
1	Muscular Dystrophies (Muscular Dystrophy) 06/2015
1	Stiff Skin Syndrome 04/2014
1	Abdominal Aortic Aneurysm 10/2013
1	Aortic Dissection 10/2013
1	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 10/2010
1	recessive Cutis laxa 08/2010
1	Peripheral Nervous System Diseases (PNS Diseases) 06/2010
1	Osteosarcoma (Osteogenic Sarcoma) 02/2010
1	Cicatrix (Scar) 05/2008
1	Hernia (Hernias) 05/2008
1	Incisional Hernia 05/2008
1	Cutis Laxa 11/2007
1	Carcinoma (Carcinomatosis) 05/2007
1	Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa) 03/2005
1	Carcinogenesis 03/2005
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/2005
1	Neoplasms (Cancer) 03/2005
1	Familial Primary Pulmonary Hypertension 01/2005
1	Mixed Connective Tissue Disease (MCTD) 01/2005
1	Systemic Scleroderma (Systemic Sclerosis) 01/2005

Drug/Important Bio-Agent (IBA)

15	Fibrillin-1IBA 01/2020 - 12/2002
6	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2005
6	FibrillinsIBA 01/2019 - 01/2005
4	Fibrillin-2IBA 06/2015 - 12/2002
3	CollagenIBA 05/2008 - 03/2005
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2020 - 01/2017
2	Transforming Growth Factor beta (TGF-beta)IBA 08/2010 - 03/2003
2	Laminin (Merosin)IBA 05/2007 - 03/2005
1	SmokeIBA 04/2022
1	1,3,4,6- tetra- O- acetyl- 2- azido- 2- deoxyglucopyranose (TAAD)IBA 01/2021
1	salicylhydroxamic acid (SHAM)IBA 01/2020
1	Pancreatic Elastase (Elastase)IBA 01/2017
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2017
1	LipidsIBA 01/2016
1	Myosins (Myosin)IBA 06/2015
1	Myosin Heavy Chains (Myosin Heavy Chain)IBA 06/2015
1	Biomarkers (Surrogate Marker)IBA 10/2013
1	Peptide Hydrolases (Proteases)FDA Link 06/2011
1	Metalloproteases (Metalloproteinases)IBA 05/2011
1	MyostatinIBA 07/2010
1	perlecanIBA 07/2010
1	Conditioned Culture MediaIBA 02/2010
1	Protein Isoforms (Isoforms)IBA 02/2010
1	Glycoproteins (Glycoprotein)IBA 05/2007
1	nidogen (entactin)IBA 05/2007
1	laminin alpha5IBA 05/2007
1	Cysteine (L-Cysteine)FDA Link 03/2006
1	Angiogenic ProteinsIBA 03/2006
1	Plasminogen Activators (Plasminogen Activator)IBA 03/2006
1	activin AIBA 03/2006
1	Fibronectins (Fibronectin)IBA 03/2005
1	Collagen Type VIIIBA 03/2005
1	Recombinant ProteinsIBA 01/2005
1	AutoantibodiesIBA 01/2005
1	Peptides (Polypeptides)IBA 01/2005
1	AntibodiesIBA 01/2005

Therapy/Procedure

1	Cardiopulmonary Resuscitation (CPR) 01/2020
1	Laparotomy 05/2008